Persons carrying out the protocols in the
laboratory may encounter various hazardous or
potentially hazardous materials including: radioactive substances; toxic chemicals and carcinogenic, mutagenic, or teratogenic reagents; and pathogenic and infectious biological
agents. Most governments regulate the use of
these materials; it is essential that they be used
in strict accordance with local and national
regulations. Cautionary notes are included in
many instances throughout the manual, and
some specific guidelines for working safely
with chemicals are provided below (and references therein). However, we emphasize that users must proceed with the prudence and precautions associated with good laboratory practice, under the supervision of personnel responsible for implementing laboratory safety programs at their institutions and in compliance with designated guidelines of federal, state, and
It is not possible in the space available to list
all the precautions to be taken when handling
hazardous chemicals. Many texts have been
written about laboratory safety; see Literature
Cited for a selected list of examples. Obviously,
all national and local laws should be obeyed as
well as all institutional regulations. Controlled
substances are regulated by the Drug Enforcement Administration. By law, Material Safety Data Sheets must be readily available. All laboratories should have a Chemical Hygiene Plan [29CFR Part 1910.1450] and institutional safety
officers should be consulted as to its implementation. Help is (or should be) available from your institutional Safety Office. Use it.
Chemicals should be stored properly. For
example, flammable chemicals (e.g., ethanol,
methanol, acetone, methyl ethyl ketone, petroleum distillates, toluene, benzene, and other materials labeled flammable) should be stored
in approved flammable storage cabinets, and
flammable chemicals requiring refrigeration...
References: LITERATURE CITED
Lunn, and Sansone, 1994
Bretherick, L. 1990. Bretherick’s Handbook of Reactive Chemical Hazards, 4th ed. Butterworths,
Forsberg, K. and Keith, L.H. 1989. Chemical Protective Clothing Performance Index Book. John
Wiley & Sons, New York.
Occupational Health and Safety. 1993. National
Safety Council, Chicago.
Forsberg and Keith, 1989. See above.
National Research Council, Committee on Hazardous Substances in the Laboratory. 1981. Prudent
Practices for Handling Hazardous Chemicals in
Aldrich Chemical Co. 2001. Aldrich Catalog Handbook of Fine Chemicals. Aldrich Chemical Co.,
Bretherick, 1990. See above.
Lewis, 1992. See above.
Lewis, R.J., Sr. 1992. Sax’s Dangerous Properties of
Industrial Materials, 8th ed
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